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Research Paper: Antibiotics produced by Bacillus subtilis
Bacillus subtilis antibiotics: structures, syntheses and specific functions The endospore-forming rhizobacterium Bacillus sub- tilis – the model system for Gram-positive organisms, is able to produce more than two dozen antibiotics with an amazing variety of structures. The produced anti-microbial active compounds include predominantly peptides that are either ribosomally synthesized and post-translationally modified (lantibiotics and lantibiotic-like peptides) or non-ribosomally generated, as well as a couple of non-peptidic compounds such as polyketides, an aminosugar, and a phospholipid. Here I summarize the structures of all known B. subtilis antibiotics, their biochemistry and genetic analysis of their biosynthesis. An updated summary of well-studied antibiotic...
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